the effect of a 12 -week endurance training on il-6, il-10 and nesfatin -1 plasma level of obese male rats
نویسندگان
چکیده
exercise training has been shown to decrease chronic low- grade systemic inflammation in high- fat diet induced obesity. however, the mechanisms mediating its beneficial effects are not fully understood. therefore, the aim of this study was to investigate the effects of a 12- week endurance training on il-6, il-10 and nesfatin -1 in obese male rats. sixteen male wistar rats (2 months old) were fed a high fat diet for 8 weeks, reaching an average weight of 319 ± 30g. the animals were randomly divided into control (n=8) and 12-week endurance training (t, n=8) groups. training group was given exercise on motor- driven treadmill at 25 to 30 m/min (0% grade), 60 min/day, 5 days/week for 12 weeks, and both groups were given “ad libitum”. the elisa method was used for laboratory analysis of nesfatin-1, il-6 and il-10. the results revealed that the average weight of rats in t group was significantly lower than that of the control group (p=0.001). a significant decrease was also observed in il-6 t group (p=0.04). nesfatin – 1 plasma level increased in t group (p=0.001). despite the fact that il-10 was lower in t group, the difference was not significant. the results of present study showed that long- term endurance training led to an increase in the anti- inflammatory nesfatin -1, and nesfatin- 1 probably plays a role in energy balance, that is independent of the changes of il-10 and il-6 in plasma level.
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عنوان ژورنال:
علوم زیستی ورزشیجلد ۵، شماره ۴، صفحات ۱۰۹-۱۲۲
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